Partners and International Organizations
(English)
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A, B, HR, CZ, DK, FIN, F, D, GR, H, IRL, I, NL, PL, P, RO, SI, E, S, CH, GB
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Abstract
(English)
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Many chemical reactions and processes involve ionic reagents, intermediates or products. Anions and cations are frequent intermediates along reaction pathways and act often as powerful nucleophiles, electrophiles, Lewis basic and acidic reagents. For our purpose, anions and cations can also be prostereogenic or chiral and most of their applications, reactions or processes lead to racemic molecular or supramolecular assemblies. To afford instead non-racemic or enantiopure products, and thus benefit from a new wealth of possible applications, we are studying projects dealing with the asymmetric chemistry of chiral anions and cations 1. The stereoselective ion pairing of chiral anions and monomethine dyes was examined (Buss and Lacour, 1 publication). A symmetry-dependant induction from the anions (C2- or D3-symmetric) onto the cations (C2-symmetric) was demonstrated. 2. The interactions of chiral thiiranium cations - powerful intermediates in synthetic chemistry - and chiral phosphate anions have been investigated. The discriminating interactions lead to a NMR non-equivalence allowing the determination the enantiomeric purity of the chiral cations (Pasquato and Lacour, 1 publication). 3. Several studies on the stereoselective synthesis of chiral coordination complexes [copper(I), iron(II), ruthenium(II)] are currently under investigation between the Strasbourg's group and ourselves. Two articles have been published and one manuscript is in preparation (Drs. Dietriech-Buchecker, Sauvage, Heitz and Lacour).
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