TAGAPO: Targeting genes and pathways in chronic immunopathologies

• Research unit: EU RFP
• Project number: 99.0581

Key words (English)

Transgenic mice; antigen presentation; CD8+ T cells; CD4+ T cells; anti-viral immunity; tolerance;
Life Sciences; Medicine; Health; Scientific Research

Alternative project number (English)

EU project number: QLG1CT199900202

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.8 Generic R&D activities

Short description (English)

See abstract

Further information (English)

Full name of research-institution/enterprise:
Universitätsspital Zürich
Departement Pathologie
Institut für Experimentelle Immunologie

Partners and International Organizations (English)

Coordinator: Hellenic Pasteur Institute, Athens (EL)

Abstract (English)

Chronic immunopathologies constitute a major class of diseases with high morbidity and mortality for the patient. TAGAPO aims to improve the current state of the art in the understanding of aetiology, pathophysiology, progress and outcome of disease by using:
1) conditional gene targeting in mice to study the impact of ablating specific cells, genes and pathways from animals developing specific immunopathologies;
2) differential gene expression profiling using DNA array technologies on important cell types to discover new genes with putative involvement in immunity and immunopathology, and
3) optimised technologies for conditional genome modification in the mouse to identify new gene function and relevance to immunity and disease.
TAGAPO build up new knowledge into mechanisms of disease pathogenesis and aims to disclose new diagnostic markers and therapeutic targets for further academic, clinical and industrial exploitation.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 99.0581