BIO-HUG: Novel bioprocesses for hemicellulose up-grading

• Research unit: EU RFP
• Project number: 99.0409

Key words (English)

Bioprocess; recycling bioaccumulable wastes; upgrading industrial byproducts; preventing industrial pollution

Alternative project number (English)

EU project number: QLK3CT199900080

Research programs (English)

EU-programme: 5. Frame Research Programme - 1.1.3 The 'cell factory'

Short description (English)

See abstract

Partners and International Organizations (English)

Coordinator: Dept of applied microbiology, Lund (S)

Abstract (English)

The aim of this work package within the whole project is strain optimization for xylose catabolism. Several improved clones were identified from previous evolution experiments and tested. With respect to xylose to ethanol conversion under industrial conditions, the best evolved strains are clearly superior to the tradionally engineering strains but also to the available industrial strains. In this second phase, we concentrated on two aspects. First, several relevant areas of mutations were identified that are used now to identify the molecular basis for the obtained improvements. This work is done in close collaboration with several partners to enable new rational metabolic engineering strategies to improve xylose catabolism. Second, the successful evolution procedure is now used also for evolution of polyploid industrial strains in collaboration with the industrial partner.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 99.0409