Schlüsselwörter
(Englisch)
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Near infrared spectroscopy; oxyhaemoglobin; cytochrome AA3; frequency modulation; time resolved spectroscopy; perinatal monitoring; finite element model; image reconstruction
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Alternative Projektnummern
(Englisch)
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EU project number: BMH4CT961658
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Forschungsprogramme
(Englisch)
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EU-programme: 4. Frame Research Programme - 4.2 Agriculture and agroindustry
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Kurzbeschreibung
(Englisch)
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See abstract
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Weitere Hinweise und Angaben
(Englisch)
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Full name of research-institution/enterprise:
EPF Lausanne
Département de Microtechnique
Laboratoire d'Optique Appliquée LOA
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Partner und Internationale Organisationen
(Englisch)
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Keele University, Universita Degli Studi Di L'aquila, University college London, University of Nottingham, Rigshospitalet, Copenhagen, Royal Postgraduate Medical School London, Universitaire Ziekenhuizen Leuven, Universitäts Frauenklinik Bonn, Women's University Hospital Wurzburg, Universita Degli Studi Florence, Universitätsspital Zürich, Ecole polytechnique fédérale de Lausanne, University of Nijmegen, Humbolt University Berlin, University of Lille
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Abstract
(Englisch)
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Near infrared techniques have emerged rapidly over recent years, offering the prospect of safe, non invasive interrogation of tissues and organs, for both biochemical measurements and for imaging. A strong european activity was established and has been pursued by a shared cost action for 18 months. Specific objectives have been targeted in five different directions: quantitative spectroscopy, perinatal monitoring, biochemistry and physiology, localized spectroscopy and imaging.
The work at EPFL-IOA (Lausanne, Switzerland) was concentrated on imaging. It essentially consisted in three parts. The first one Was to improve and validate the model of light transport in tissues (forward model) using phantoms. The second one was to participate in providing data for the development of
Reconstruction algorithm (inverse model) which was mainly developed at university college (London) and investigating therefore the accuracy of the forward model in a quantitative way. Finally the IOA-EPFL was involved in the use and development of tissue equivalent phantoms, with properties and geometry
Representative of the human breast. These phantoms were employed in the various aspects of nir imaging of breast. A frequency-domain apparatus was built to transilluminate diffusive media. The performances of this set-up were established by scanning specific phantoms provided by UCL (London) and known to be as 'closed to the limitations of what was possible to detect'. Since these phantoms were lent to us by Jem Hebden (UCL) who had already made time-domain measurements on them, we had
The opportunity of comparing both time- and frequency-domain results. The next part was to develop a forward model which lead frequency-domain simulated results used to assess our experimental measurements. These tasks were successfully achieved and have yielded encouraging results on the
Capabilities of such equipments to image even small tumors (<1 cm) in the breast.
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Datenbankreferenzen
(Englisch)
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Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. +41 31 322 74 82
Swiss Project-Number: 95.0701-2
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