Decoding How Activation Duration Drives GPCR Signalling: An Optogenetic-Based Approach to GPCR Kinetics

• Unité de recherche: INNOSUISSE
• Numéro de projet: 137.956 IP-LS
• Titre du projet anglais: Decoding How Activation Duration Drives GPCR Signalling: An Optogenetic-Based Approach to GPCR Kinetics

Mots-clé (Anglais)

Life sciences, Biotechnology and processing

Résumé des résultats (Abstract) (Anglais)

GPCRs are the most common drug target in medicine, yet how long a drug must activate its receptor to trigger a specific cellular response remains unknown. This project uses bistable opto-GPCRs and mathematical modelling to determine pathway activation duration thresholds for rational drug discovery.