Validation and Expansion of the HelixScreen 3D Ex Vivo Drug Screening Platform for Colorectal Cancer and Antibody-Drug Conjugate Screening

• Unité de recherche: INNOSUISSE
• Numéro de projet: 137.138 INNO-LS
• Titre du projet anglais: Validation and Expansion of the HelixScreen 3D Ex Vivo Drug Screening Platform for Colorectal Cancer and Antibody-Drug Conjugate Screening

Mots-clé (Anglais)

Life sciences, Human medicine

Résumé des résultats (Abstract) (Anglais)

This research evaluates HelixScreen - a high?throughput and rapid drug testing platform with transcriptomic profiling on 3D tumor cultures, that guides ADC payload selection and reveals antibody penetration in solid tumors, surpassing genomic?only or patient-derived xenograft limits.