Identification of genes responsible for immotile cilia syndrome (ICS)

• Research unit: EU RFP
• Project number: 95.0458-2

Key words (English)

Kartagener syndrome; immotile cilia syndrome; primary ciliary dyskinesia; situs inversus; cilia; animal models

Alternative project number (English)

EU project number: PL950302

Research programs (English)

EU-programme: 4. Frame Research Programme - 4.2 Agriculture and agroindustry

Short description (English)

See abstract

Partners and International Organizations (English)

Freie Universität Berlin (D), Université de Genève (CH), Hospital General Universitno de Valencia (E), CNRS Montpellier (F), University College London, Imperial Cancer Research Fund (GB), Università di Pavia (I), Katholeike Universiteit
Leuven (B)

Abstract (English)

We continued to collect blood from potentially affected Immotile-Cilia-Syndrome (ICS)-families until the end of the project planned (1998). Blood was sent to Professor S. Antonarakis' group at the division of medical genetics, CMU, Geneva, for a genome-wide linkage analysis. There is a publication on the way, which will be prepared by Dr. J.L. Bloum (first author) as a result of the common efforts of the centers involved. ˆDue to the activities during this BIOMED project we hope that we will be able to better diagnbse patients with such ciliary problems.
In order to study the problem of ICS on a new basis, we begun to study model situations where the problem can be investigated more basically. One of these possibilities is an investigation of the cilia of the Irish Woolfhound. These animals have a number of clinical problems in common with the human counterpart and since these dogs are animal patients we are in collaboration with Dres. PD S. Arnold and I. Reichler from the Animal Hospital of Zurich. As the BIOMED project comes to an end, we will maintain our well established collaboration with a number of colleages we appreciate since the start of this project.

References in databases (English)

Swiss Database: Euro-DB of the
State Secretariat for Education and Research
Hallwylstrasse 4
CH-3003 Berne, Switzerland
Tel. [phone]
Swiss Project-Number: 95.0458-2