Optimizing payload bioavailability in antibody drug conjugates that target DNA replication stress

• Unité de recherche: INNOSUISSE
• Numéro de projet: 135.942 IP-LS
• Titre du projet anglais: Optimizing payload bioavailability in antibody drug conjugates that target DNA replication stress

Mots-clé (Anglais)

Life sciences, Chemical biology

Résumé des résultats (Abstract) (Anglais)

Antibody Drug conjugates (ADCs) are limited by toxic, poorly diversified payloads and emerging resistance. We are developing a novel, cancer-selective class of ADC payloads targeting DNA replication stress, offering an expanded therapeutic window and an option when resistance to current ADCs occurs.