Optimizing payload bioavailability in antibody drug conjugates that target DNA replication stress

• Forschungsstelle: INNOSUISSE
• Projektnummer: 135.942 IP-LS
• Projekttitel Englisch: Optimizing payload bioavailability in antibody drug conjugates that target DNA replication stress

Schlüsselwörter (Englisch)

Life sciences, Chemical biology

Abstract (Englisch)

Antibody Drug conjugates (ADCs) are limited by toxic, poorly diversified payloads and emerging resistance. We are developing a novel, cancer-selective class of ADC payloads targeting DNA replication stress, offering an expanded therapeutic window and an option when resistance to current ADCs occurs.