Development of Clinically Translatable PLGA?iLNP Hybrid Nanoparticles for Mutation-Agnostic CFTR mRNA Therapy

• Unité de recherche: INNOSUISSE
• Numéro de projet: 137.048 INNO-LS
• Titre du projet anglais: Development of Clinically Translatable PLGA?iLNP Hybrid Nanoparticles for Mutation-Agnostic CFTR mRNA Therapy

Mots-clé (Anglais)

Life sciences, Personalised medicine

Résumé des résultats (Abstract) (Anglais)

PLGA?ionizable lipid hybrid nanoparticles are developed as a PEG-free pulmonary delivery system for mutation-agnostic CFTR mRNA therapy. The project systematically optimizes hybrid nanoparticle architecture to enable repeat-dose?compatible, clinically translatable CFTR restoration in cystic fibrosis