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Research unit
INNOSUISSE
Project number
137.048 INNO-LS
Project title
Development of Clinically Translatable PLGA?iLNP Hybrid Nanoparticles for Mutation-Agnostic CFTR mRNA Therapy

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CategoryText
Key words
(English)
Life sciences, Personalised medicine
Abstract
(English)
PLGA?ionizable lipid hybrid nanoparticles are developed as a PEG-free pulmonary delivery system for mutation-agnostic CFTR mRNA therapy. The project systematically optimizes hybrid nanoparticle architecture to enable repeat-dose?compatible, clinically translatable CFTR restoration in cystic fibrosis