TOP-N53 and PLGA Based Dissolving Microneedles for Transdermal Restoration of Microcirculation in Systemic Sclerosis Patients.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 108.683 INT-LS
• Titre du projet anglais: TOP-N53 and PLGA Based Dissolving Microneedles for Transdermal Restoration of Microcirculation in Systemic Sclerosis Patients.

Mots-clé (Anglais)

Life sciences, Pharmaceuticals, Material sciences

Résumé des résultats (Abstract) (Anglais)

Systemic sclerosis (SSc) is a debilitating rare disease. By developing microneedles that contain slow-release PLGA microspheres loaded with TOP-N53, a drug that combines NO donor and PDE5 inhibitor, we aim to mitigate secondary Raynaud's Phenomenon (RP) and prevent digital ulcers in SSc patients.