PyoBeta: Pyoverdine-?-lactam prodrugs as novel antimicrobials against antibiotic-resistant bacteria

• Unité de recherche: INNOSUISSE
• Numéro de projet: 132.720 IP-LS
• Titre du projet anglais: PyoBeta: Pyoverdine-?-lactam prodrugs as novel antimicrobials against antibiotic-resistant bacteria

Mots-clé (Anglais)

Life sciences, Biotechnology and processing

Résumé des résultats (Abstract) (Anglais)

We are developing a new class of antimicrobials that exploit bacterial iron dependency to treat systemic infections caused by WHO priority pathogens. Engineered pyoverdine-based prodrugs activate only at infection sites, starving pathogens of iron.