A Gene Engineering Platform for Scalable, Off-the-Shelf CAR T-Cell Therapies

• Unité de recherche: INNOSUISSE
• Numéro de projet: 132.134 IP-LS
• Titre du projet anglais: A Gene Engineering Platform for Scalable, Off-the-Shelf CAR T-Cell Therapies

Mots-clé (Anglais)

Life sciences, Genetic engineering

Résumé des résultats (Abstract) (Anglais)

Chimeric Antigen Receptor (CAR) therapy traditionally relies on engineering autologous T cells, limiting scalability. We developed a single-vector platform for multi-gene modulation, generating 'off-the-shelf' allogeneic CAR T cells from healthy donors, enabling one donor to treat multiple patients.