Novel signaling node and pharmacology in (pseudo-) allergic hypersensitivity

• Unité de recherche: INNOSUISSE
• Numéro de projet: 130.659 IP-LS
• Titre du projet anglais: Novel signaling node and pharmacology in (pseudo-) allergic hypersensitivity

Mots-clé (Anglais)

Life sciences, Pharmaceuticals

Résumé des résultats (Abstract) (Anglais)

Drug-induced hypersensitivity (DIH) prevention is an unmet medical need. We linked a novel target to DIH, and aim to evolve inhibitor series with new pharmacology, unmatched specificity and potency. Our genetic and pharmacologic DIH mouse models highlight a path to cost efficient clinical trials.