First-in-Class PAM Targeting Adenosine 2A Receptor: Developmental Candidate Selection and Validation of Autoimmune Disease Indications

• Unité de recherche: INNOSUISSE
• Numéro de projet: 121.127 IP-LS
• Titre du projet anglais: First-in-Class PAM Targeting Adenosine 2A Receptor: Developmental Candidate Selection and Validation of Autoimmune Disease Indications

Mots-clé (Anglais)

Life sciences, Pharmaceuticals

Résumé des résultats (Abstract) (Anglais)

Adenosine 2A receptor (A2AR) signaling dysregulation results in inflammatory diseases. This project focuses on reaching the developmental drug candidate stage for positive allosteric modulators (PAMs) for A2AR and selecting the most relevant inflammatory therapeutic area(s) for their application.