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Research unit
INNOSUISSE
Project number
124.461 IP-LS
Project title
Designing allosteric activators of CSE as novel oral inhibitors of pathologic calcification

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CategoryText
Key words
(English)
Life sciences, Pharmaceuticals
Abstract
(English)
SULFISCON is developing small molecule activators of the enzyme CSE to modulate endogenous H2S production as a drug. We seek support to optimise pharmacologic properties of current lead compounds for oral administration and test their effects in animal models of pathologic calcification.