Biosensor-Based Diagnostic Platform Enabling Real-Time Monitoring of Existing and Emerging Pollutants

Schrift Standard Fett
Login

Forschungsstelle

SBFI

Projektnummer

24.00108

Projekttitel

Biosensor-Based Diagnostic Platform Enabling Real-Time Monitoring of Existing and Emerging Pollutants

Texte zu diesem Projekt

	Deutsch	Französisch	Italienisch	Englisch
Abstract	-	-	-

Erfasste Texte

Kategorie	Text
Abstract (Englisch)	BIOSENSEI develops a real-time, multiplexed, end-to-end, tailored and reliable biosensor platform, using cellular responses, fordetection of abiotic pollutants - Nutrients, Estrogenic endocrine-disrupting chemicals, and PFAS (Perfluoroalkyl and PolyfluoroalkylSubstances); and biotic pollutants - Microcystins. Cellular biosensors from bacterial variants will be genetically engineered using, RNARNAinteractive and type III CRISPR-Cas-mediated transduction cascades. These biosensors are encapsulated and immobilised at bimodaltransducers (nanoelectrochemical and optical) to provide highly reliable, tuneable and sensitive detection of the target pollutants.Bespoke ultra-low power analog front ends and autonomous IoT end-nodes will enable operation and data acquisition from biosensorsand facilitate easy integration in existing LoRa networks enabling real-time data feeds. Neural computing algorithms are embedded on theedge to correct for sensor aging and interferents in the (bio)chemical transduction and improve sensor data accuracy. An online dashboardwill be developed to allow end users to visualize data. BIOSENSEI will embed the whole R&D process within a safe-and-sustainable-bydesignframework to guarantee environmental safety related to risks of potential release into the open environment. Biosensors will bescalable, adaptable to different applications in water & soil and will be deployed in four different use-cases. The consortium is verticallyintegrated bringing expertise in cellular biology, surface chemistry, nanoelectronics fabrication, hardware integration, regulatoryand industrial sampling and artificial intelligence. BIOSENSEI directly addresses HORIZON-CL6-2023-ZEROPOLLUTION-01-6Biosensors and user-friendly diagnostic tools for environmental services and will allow cellular biosensors to be deployed outsidelaboratory settings for the first time the project and has the potential to considerably contribute to fulfil EU vision on zero-pollution.

Kategorie

Text

Abstract
(Englisch)

BIOSENSEI develops a real-time, multiplexed, end-to-end, tailored and reliable biosensor platform, using cellular responses, fordetection of abiotic pollutants - Nutrients, Estrogenic endocrine-disrupting chemicals, and PFAS (Perfluoroalkyl and PolyfluoroalkylSubstances); and biotic pollutants - Microcystins. Cellular biosensors from bacterial variants will be genetically engineered using, RNARNAinteractive and type III CRISPR-Cas-mediated transduction cascades. These biosensors are encapsulated and immobilised at bimodaltransducers (nanoelectrochemical and optical) to provide highly reliable, tuneable and sensitive detection of the target pollutants.Bespoke ultra-low power analog front ends and autonomous IoT end-nodes will enable operation and data acquisition from biosensorsand facilitate easy integration in existing LoRa networks enabling real-time data feeds. Neural computing algorithms are embedded on theedge to correct for sensor aging and interferents in the (bio)chemical transduction and improve sensor data accuracy. An online dashboardwill be developed to allow end users to visualize data. BIOSENSEI will embed the whole R&D process within a safe-and-sustainable-bydesignframework to guarantee environmental safety related to risks of potential release into the open environment. Biosensors will bescalable, adaptable to different applications in water & soil and will be deployed in four different use-cases. The consortium is verticallyintegrated bringing expertise in cellular biology, surface chemistry, nanoelectronics fabrication, hardware integration, regulatoryand industrial sampling and artificial intelligence. BIOSENSEI directly addresses HORIZON-CL6-2023-ZEROPOLLUTION-01-6Biosensors and user-friendly diagnostic tools for environmental services and will allow cellular biosensors to be deployed outsidelaboratory settings for the first time the project and has the potential to considerably contribute to fulfil EU vision on zero-pollution.