Radioligand therapy targeting B7-H3: A novel nanobody-polymer conjugate to treat incurable brain tumors

• Unité de recherche: INNOSUISSE
• Numéro de projet: 120.930 IP-LS
• Titre du projet anglais: Radioligand therapy targeting B7-H3: A novel nanobody-polymer conjugate to treat incurable brain tumors

Mots-clé (Anglais)

Life sciences, Pharmaceuticals

Résumé des résultats (Abstract) (Anglais)

We are pioneering a clinical candidate for targeted radioligand therapy against incurable brain tumors. Our focus is to develop a nanobody-radionuclide conjugate comprising a novel polymer carrier to enhance blood brain barrier penetration (BBBP), tumor acuumulation and reduce kidney uptake.