Proof-of-concept of narcolepsy reversal by epigenetic therapy

• Unité de recherche: INNOSUISSE
• Numéro de projet: 119.682 IP-LS
• Titre du projet anglais: Proof-of-concept of narcolepsy reversal by epigenetic therapy

Mots-clé (Anglais)

Life sciences, Human medicine

Résumé des résultats (Abstract) (Anglais)

We discovered that narcolepsy causation involves epigenetic silencing of the HCRT gene by DNA hypermethylation. We designed an innovative in vitro?in vivo strategy as proof-of-concept of HCRT gene reactivation leading to the development of the 1st disease- modifying therapy for narcolepsy.