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Research unit
INNOSUISSE
Project number
119.682 IP-LS
Project title
Proof-of-concept of narcolepsy reversal by epigenetic therapy

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CategoryText
Key words
(English)
Life sciences, Human medicine
Abstract
(English)
We discovered that narcolepsy causation involves epigenetic silencing of the HCRT gene by DNA hypermethylation. We designed an innovative in vitro?in vivo strategy as proof-of-concept of HCRT gene reactivation leading to the development of the 1st disease- modifying therapy for narcolepsy.