Abstract
(Englisch)
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BETTER4U aims at the identification and personalized management of all weight gain determinants to battle the increasinglyrising numbers of overweight/obesity, via homogenous, globally adaptable and practically assessed public health initiatives and keyinterventions. Building on previous key projects and biobanks, the project will focus on the hitherto neglected impact of the polygenicbackground of weight gain on the effectiveness of lifestyle interventions for weight management in people with overweight/obesity.BETTER4U aims to probe into the global obesity challenge, study the problem and offer solutions in a tangible realistic way withthe assistance of modern AI technologies and the contribution of experts around the world. BETTER4U will be realized through thefollowing objectives: 1. To comprehensively understand and decipher genetics, metabolomics, microbiota, socio-economic, geographical,cultural and lifestyle features linked to weight gain throughout the life course, via meta-analyses (BETTER4U data from >50 studies,>1 million individuals) and extensive literature meta-review. 2.To develop the BETTER4U intervention methodology for weight gainprevention, based on a causal AI model of obesity determinants and a pilot study in 7 European countries. 3.To deploy technologyassisted,real-time monitoring tools to measure detailed behavioral indicators and their relation to the environmental context. 4.To evaluatethe efficacy of the novel BETTER4U intervention methodology in a controlled, randomized clinical trial, based on individually-tailoredrecommendations for lifestyle change. 5.To maximize transferability and applicability of the BETTER4U intervention methodologyby identifying implementation barriers and facilitators, as well as to evaluate implementation outcomes in both participants andstakeholders. 6. To develop and disseminate the BETTER4Uobesity prevention intervention methodology guidelines using a peoplecentred,sustainable care approach.
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