To comply with the timeline of Swiss net-zero targets, an accelerated market development of sustainable fuels and platform chemicals is necessary. While first-generation technology is available to initiate a ramp-up the production of those substances, this is not the case for policies, laws, regulations, and markets (non-technical aspects). A first aim of the reFuel.ch project is therefore concerned with investigating how investment security can be improved by closing these knowledge gaps. This must be done carefully, based on a broad understanding of sustainability criteria, to avoid misguided decisions and detrimental effects on future developments and implementation. The reFuel.ch Consortium will develop robust and practical pathways for introducing sustainable fuels and platform chemicals to markets and the Swiss energy system (including unused domestic biomass) using an inter- and transdisciplinary approach. This will include inputs from social science (sociology, law, economics, and political science), natural sciences, and engineering, as well as the dialogue with policy makers, regulators, market actors, and end users - via regular thematic Round Table discussions. Within this framework, case studies for domestic, European, and non-European implementations will be evaluated and co-designed. A second aim is to strengthen innovative technologies currently at low technology readiness level. This will be achieved by focusing on green methanol pathways and other technologies with breakthrough potential for sustainable fuel and platform chemical production. The overall target is to improve sustainability and reduce costs by increasing efficiency, selectivity, and load-flexibility of plants in order to comply with long-term climate policy goals.