Covalent proximity scanning ? unleashing covalent PI3Kalfa inhibitors for cancer

• Unité de recherche: INNOSUISSE
• Numéro de projet: 108.486 IP-LS
• Titre du projet anglais: Covalent proximity scanning ? unleashing covalent PI3Kalfa inhibitors for cancer

Mots-clé (Anglais)

Life sciences, Human medicine

Résumé des résultats (Abstract) (Anglais)

PI3K? is a high value target in cancer. Response duration and tolerability of approved PI3K? drugs is limited. With our proprietary CoPS platform for covalent inhibitor deployment, we will generate novel covalent PI3K? inhibitors with enhanced specificity and potency ready for clinical development.