Boosting the development of novel bacteriophage-derived antimicrobials to fight antibiotic-resistant Pseudomonas and Enterococcus infections

• Unité de recherche: INNOSUISSE
• Numéro de projet: 104.969 IP-LS
• Titre du projet anglais: Boosting the development of novel bacteriophage-derived antimicrobials to fight antibiotic-resistant Pseudomonas and Enterococcus infections

Mots-clé (Anglais)

Life sciences, Pharmaceuticals

Résumé des résultats (Abstract) (Anglais)

Novel, patentable bacteriophage-based precision antimicrobials are generated. To minimize the risk of failure at the pre-clinical stage, in vivo activity screening in zebrafish embryos is combined with process development, continuous evolution, and phage engineering during early stages of discovery.