Résumé des résultats (Abstract)
(Anglais)
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The incidence of undiagnosed diabetes accounts for 36% European adults, while 541M adults worldwide have Impaired Glucose
Tolerance (IGT), an important risk factor for further T2D development. Both IGT and/or Impaired Fasting Glucose (IFG) are intermediate
glucose mishandling (i.e. intermediate conditions in the healthy-T2D transition) and are manifestations of the so-called prediabetes
condition. Prediabetes itself is not an extensively studied condition compared to the overt T2D, but it is also a condition that can be
reversed without the prescription usage to not proceed into T2D. The aim of our project is to develop a prototype tool for the real-time
prediction of the prediabetic risk based on a series of patient-specific mathematical models (firstly developed during the FP7 MISSIONT2D
project) that simulate metabolism, pancreas hormone production, microbiome metabolites, inflammatory process and immune
system response. The prediction algorithm will be based on a “physics-informed machine learning” approach. A rich dataset of real-life
data will be combined with a mathematical model to overcome the limits of a “black-box” ML approach, while reducing the computational
time for simulating the solutions of a heavy mathematical models and improving its prediction performances.We will collect the necessary
training data (e.g., diet questionnaire, physical activity, blood metabolites and microbiome) from already existing clinical studies (used
as retrospective trials) which are representative of the real-life scenarios of a prediabetes/diabetes risk insurgence in adulthood (20-80y):
family history, Metabolic Syndrome, Liver disease and obesity. A newly dedicated multicentric pilot prospective observational study
will be also performed, during which we will also equip the participants with wearable sensors (e.g. glucose monitoring, bioimpedance,
heart rate, accelerometer).
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