Abstract
(Englisch)
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Here we, a group of long-standing collaborators in innovative drug repurposing, propose to build REPO4EU, a comprehensive European/global
platform for validated precision drug repurposing open to stakeholders for information, multimedia training, matchmaking and cooperation. Drug
repurposing reduces the time and costs of drug development but is often serendipitous and less effective than classical drug discovery. Both,
discovery and repurposing, suffer from the same knowledge gap that diseases are mechanistically not understood and treated symptomatically in
an imprecise manner. Our team of world-leading scientists overcome this by breakthroughs in advanced bioinformatics and artificial intelligence
(AI) on real-world big data to redefine diseases in a mechanism-based manner. Patients are still identified by symptom, but stratified according to
causal mechanism, the endotype. Trials are small, precise, innovatively designed, prioritising, in coordination with regulators, payers and
investors, patient-defined outcomes with high safety and operational excellence. This revolutionary new era of medicine will allow unprecedented
efficacy and cost-effectiveness. The promiscuity of small molecules and recently expanded knowledge of protein structures are exploited by
cheminformatics and deep learning to repurpose drugs beyond their original target. At any level of the development chain, even for classic
projects, REPO4EU provides expertise and matchmaking for freedom-to-operate, intellectual property, reformulation and value-creation,
specialised in drug repurposing. Within 5 years, REPO4EU will establish a first-in-class coherent and innovative web-based platform for safe and
efficient drug repurposing for all types of high unmet medical need indications to all European researchers and SMEs with a unique Open Science
concept, ensuring global medical impact. Finally, within a 2-year interphase, REPO4EU will be converted into a sustainable European
infrastructure.
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