Adenosine 2A receptor reactivation by positive allosteric modulators as a new therapeutic venue for unmet medical need in chronic inflammation (Innolink: 102.479 IP-LS)

• Unité de recherche: INNOSUISSE
• Numéro de projet: 62422.1 IP-LS
• Titre du projet anglais: Adenosine 2A receptor reactivation by positive allosteric modulators as a new therapeutic venue for unmet medical need in chronic inflammation (Innolink: 102.479 IP-LS)

Description succincte (Allemand)

Adenosine 2A receptor reactivation by positive allosteric modulators as a new therapeutic venue for unmet medical need in chronic inflammation (Innolink: 102.479 IP-LS)

Description succincte (Anglais)

Adenosine 2A receptor reactivation by positive allosteric modulators as a new therapeutic venue for unmet medical need in chronic inflammation

Résumé des résultats (Abstract) (Allemand)

Based on new insights, past SAR campaigns are being re-challenged and rationalized for further hit-to-lead chemical optimization and future drug candidate selection. The project strength lies in the drug allosteric mode of action, an innovative and safer approach to chronic inflammation treatments.