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Research unit
INNOSUISSE
Project number
120.434 IP-LS
Project title
Preclinical in vivo proof of mechanism study of selective mTORC1 inhibitors

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CategoryText
Key words
(English)
Life sciences, Pharmaceuticals
Abstract
(English)
Increased activity of mammalian target of rapamycin complex 1 (mTORC1) is linked to multiple disorders. We identified ten small compounds that selectively and efficiently inhibit mTORC1 in vitro with an innovative mode of action. We now aim to achieve preclinical proof of mechanism in mice.