A2AR negative allosteric modulators for cancer immunotherapy: validation of lead candidate

• Unité de recherche: INNOSUISSE
• Numéro de projet: 46357.1 IP-LS
• Titre du projet anglais: A2AR negative allosteric modulators for cancer immunotherapy: validation of lead candidate

Description succincte (Allemand)

A2AR negative allosteric modulators for cancer immunotherapy: validation of lead candidate

Description succincte (Anglais)

A2AR negative allosteric modulators for cancer immunotherapy: validation of lead candidate

Résumé des résultats (Abstract) (Allemand)

We are discovering small molecules, currently at the validated hit stage, to augment anti-cancer immunity by blocking the adenosine 2A receptor (A2AR) pathway. A desirable and unique feature of our approach is the 'allosteric' mode of binding to A2AR.