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Research unit
FSVO
Project number
1.21.13
Project title
ICRAD CAE-RAPID Development of a rapid screening test for on-site serological di-agnostics of caprine arthritis-encephalitis using individual milk samples

Texts for this project

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Key words
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Short description
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Project aims
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Key words
(German)

Afrikanische Schweinepest, Persistenz, Resistenz, Immunantwort

Short description
(English)

The objective of CAE-RAPID is to develop a rapid immunochromatographic diagnostic test (point-of-care test) for caprine arthritis encephalitis (CAE).

CAE-RAPID aims to improve individual diagnostics of CAE by providing an easily available and convenient tool for reliable exclusion and early detection of the disease. The rapid test for detection of antibodies to SRLV in a drop of milk, serum, or whole blood will be intended for use in two basic situations. First, for on-site quick screening of asymptomatic goats which are intended to be purchased or introduced into the herd. Second, for on-site quick screening of goats in which ?rst clinical signs have emerged. The test will be a screening diagnostic method so it will be expected to maximize diagnostic sensitivity and the negative predictive value, so that a goat that tests negative can be safely introduced into or retained in the herd. Positive results will need veri?cation in the laboratory.
Project aims
(English)
- Isolation und characterization of SRLV field strains.
- Production and purification of whole-virus antigen and recombinant SRLV proteins such as Env and Gag.
- Integrate these antigens in a point-of-care, rapid immunochromatographic diagnostic test.
Publications / Results
(German)
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