Developing a next-generation targeted anti-fibrotic therapy for heart failure in a porcine model

• Unité de recherche: INNOSUISSE
• Numéro de projet: 40379.1 IP-LS
• Titre du projet anglais: Developing a next-generation targeted anti-fibrotic therapy for heart failure in a porcine model

Description succincte (Allemand)

Developing a next-generation targeted anti-fibrotic therapy for heart failure in a porcine model

Description succincte (Anglais)

Developing a next-generation targeted anti-fibrotic therapy for heart failure in a porcine model

Résumé des résultats (Abstract) (Allemand)

The project aims to demonstrate translational proof of concept of a Wisper-targeting antisense therapy in a porcine model of myocardial infarction and to gain further understanding of how doses, pharmacodynamics, and pharmacokinetics translate for this first-in-class therapeutic target.