Development of a new Class of Antibiotics Inhibiting the LPS Transport Pathway

• Forschungsstelle: INNOSUISSE
• Projektnummer: 120.347 IP-LS
• Projekttitel Englisch: Development of a new Class of Antibiotics Inhibiting the LPS Transport Pathway

Schlüsselwörter (Englisch)

Life sciences, Pharmaceuticals

Abstract (Englisch)

Inhibitors against components of the LPS biosynthesis pathway as drugs against Gram-negative bacteria are developed using protein epitope mapping technology (PEM) developed by Polyphor. Structural data and studies to understand off-targeting are conducted at UZH to obtain preclinical candidates.