3D human liver microtissue-based in vitro assay for perdicting metabolic stability of low clearance compounds in pharmaceutical drug development

• Forschungsstelle: INNOSUISSE
• Projektnummer: 25720.1 PFLS-LS

Kurzbeschreibung (Deutsch)

3D human liver microtissue-based in vitro assay for perdicting metabolic stability of low clearance compounds in pharmaceutical drug development

Kurzbeschreibung (Englisch)

Abstract (Deutsch)

The projects aims at developing an in vitro assay based on primary human 3D spherical microtissues and microfluidic technology for analyzing pharmacokinetics of new compounds. The focus lies on low clearance substances and their stability over time in relation to liver metabolism.

Abstract (Englisch)