Establishment of a fully synthetic, mirror-image biological system

• Unité de recherche: INNOSUISSE
• Numéro de projet: 19069.1 PFLS-LS
• Titre du projet anglais: Establishment of a fully synthetic, mirror-image biological system

Description succincte (Allemand)

Establishment of a fully synthetic, mirror-image biological system

Description succincte (Anglais)

Establishment of a fully synthetic, mirror-image biological system

Résumé des résultats (Abstract) (Allemand)

Our goal is to create a mirror-image synthetic biology, independent of nature. Starting from L-nucleotides and D-amino acids, we will use chemical synthesis to establish a functioning mirror-image biological system from artificial components. There are immediate practical outcomes: D-DARPins will not be substrates of natural proteases, permitting oral application, and they may fundamentally overcome immunogenicity even in fusion proteins as therapeutic principles.

Résumé des résultats (Abstract) (Anglais)

Our goal is to create a mirror-image synthetic biology, independent of nature. Starting from L-nucleotides and D-amino acids, we will use chemical synthesis to establish a functioning mirror-image biological system from artificial components. There are immediate practical outcomes: D-DARPins will not be substrates of natural proteases, permitting oral application, and they may fundamentally overcome immunogenicity even in fusion proteins as therapeutic principles.