Establishment of a fully synthetic, mirror-image biological system - Texts

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Research unit

INNOSUISSE

Project number

19069.1 PFLS-LS

Project title

Establishment of a fully synthetic, mirror-image biological system

Texts for this project

	German	French	Italian	English
Short description		-	-
Abstract		-	-

Inserted texts

Category	Text
Short description (German)	Establishment of a fully synthetic, mirror-image biological system
Short description (English)	Establishment of a fully synthetic, mirror-image biological system
Abstract (German)	Our goal is to create a mirror-image synthetic biology, independent of nature. Starting from L-nucleotides and D-amino acids, we will use chemical synthesis to establish a functioning mirror-image biological system from artificial components. There are immediate practical outcomes: D-DARPins will not be substrates of natural proteases, permitting oral application, and they may fundamentally overcome immunogenicity even in fusion proteins as therapeutic principles.
Abstract (English)	Our goal is to create a mirror-image synthetic biology, independent of nature. Starting from L-nucleotides and D-amino acids, we will use chemical synthesis to establish a functioning mirror-image biological system from artificial components. There are immediate practical outcomes: D-DARPins will not be substrates of natural proteases, permitting oral application, and they may fundamentally overcome immunogenicity even in fusion proteins as therapeutic principles.