Development of early lead-like small molecules targeting a bacterial transcriptional regulator to treat infections caused by the Gram-negative pathogen Acinetobacter baumannii.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18838.1 PFLS-LS
• Titre du projet anglais: Development of early lead-like small molecules targeting a bacterial transcriptional regulator to treat infections caused by the Gram-negative pathogen Acinetobacter baumannii.

Description succincte (Allemand)

Development of early lead-like small molecules targeting a bacterial transcriptional regulator to treat infections caused by the Gram-negative pathogen Acinetobacter baumannii.

Description succincte (Anglais)

Development of early lead-like small molecules targeting a bacterial transcriptional regulator to treat infections caused by the Gram-negative pathogen Acinetobacter baumannii.

Résumé des résultats (Abstract) (Allemand)

Acinetobacter baumannii is a Gram-negative bacterium of the ESKAPE-pathogen group and listed as one of the top priority dangerous organisms. The majority of clinical A. baumannii isolates (63%) are multidrug resistant. This project aims at developing an early lead-like small molecule against a transcriptional regulator of Acinetobacter ssp. These molecules will represent a new class of antibiotics active against a novel target family in Gram-negative antibacterial research.

Résumé des résultats (Abstract) (Anglais)

Acinetobacter baumannii is a Gram-negative bacterium of the ESKAPE-pathogen group and listed as one of the top priority dangerous organisms. The majority of clinical A. baumannii isolates (63%) are multidrug resistant. This project aims at developing an early lead-like small molecule against a transcriptional regulator of Acinetobacter ssp. These molecules will represent a new class of antibiotics active against a novel target family in Gram-negative antibacterial research.