Development of early lead-like small molecules targeting a bacterial transcriptional regulator to treat infections caused by the Gram-negative pathogen Acinetobacter baumannii.

• Research unit: INNOSUISSE
• Project number: 18838.1 PFLS-LS

Short description (German)

Development of early lead-like small molecules targeting a bacterial transcriptional regulator to treat infections caused by the Gram-negative pathogen Acinetobacter baumannii.

Short description (English)

Development of early lead-like small molecules targeting a bacterial transcriptional regulator to treat infections caused by the Gram-negative pathogen Acinetobacter baumannii.

Abstract (German)

Acinetobacter baumannii is a Gram-negative bacterium of the ESKAPE-pathogen group and listed as one of the top priority dangerous organisms. The majority of clinical A. baumannii isolates (63%) are multidrug resistant. This project aims at developing an early lead-like small molecule against a transcriptional regulator of Acinetobacter ssp. These molecules will represent a new class of antibiotics active against a novel target family in Gram-negative antibacterial research.

Abstract (English)

Acinetobacter baumannii is a Gram-negative bacterium of the ESKAPE-pathogen group and listed as one of the top priority dangerous organisms. The majority of clinical A. baumannii isolates (63%) are multidrug resistant. This project aims at developing an early lead-like small molecule against a transcriptional regulator of Acinetobacter ssp. These molecules will represent a new class of antibiotics active against a novel target family in Gram-negative antibacterial research.