Engineered arrestins as novel biosensors for drug-induced GPCR phosphorylation

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18540.1 IP-LS
• Titre du projet anglais: Engineered arrestins as novel biosensors for drug-induced GPCR phosphorylation

Description succincte (Allemand)

Engineered arrestins as novel biosensors for drug-induced GPCR phosphorylation

Description succincte (Anglais)

Engineered arrestins as novel biosensors for drug-induced GPCR phosphorylation

Résumé des résultats (Abstract) (Allemand)

Promising drug candidates entering pre- and clinical trials account for more than 50% of the total Pharma R&D|spending and have a failure rate of 95%. About half of them target GPCRs, an important superfamily of|membrane receptors. For better and earlier assessment of quality, safety, and effectiveness of drug|candidates, we will develop cellular screening systems on a unique arrestin-engineering platform to enable|high-throughput dissection of drug-induced GPCR signaling.

Résumé des résultats (Abstract) (Anglais)

Promising drug candidates entering pre- and clinical trials account for more than 50% of the total Pharma R&D|spending and have a failure rate of 95%. About half of them target GPCRs, an important superfamily of|membrane receptors. For better and earlier assessment of quality, safety, and effectiveness of drug|candidates, we will develop cellular screening systems on a unique arrestin-engineering platform to enable|high-throughput dissection of drug-induced GPCR signaling.