Engineered arrestins as novel biosensors for drug-induced GPCR phosphorylation

• Research unit: INNOSUISSE
• Project number: 18540.1 IP-LS

Short description (German)

Engineered arrestins as novel biosensors for drug-induced GPCR phosphorylation

Short description (English)

Engineered arrestins as novel biosensors for drug-induced GPCR phosphorylation

Abstract (German)

Promising drug candidates entering pre- and clinical trials account for more than 50% of the total Pharma R&D|spending and have a failure rate of 95%. About half of them target GPCRs, an important superfamily of|membrane receptors. For better and earlier assessment of quality, safety, and effectiveness of drug|candidates, we will develop cellular screening systems on a unique arrestin-engineering platform to enable|high-throughput dissection of drug-induced GPCR signaling.

Abstract (English)

Promising drug candidates entering pre- and clinical trials account for more than 50% of the total Pharma R&D|spending and have a failure rate of 95%. About half of them target GPCRs, an important superfamily of|membrane receptors. For better and earlier assessment of quality, safety, and effectiveness of drug|candidates, we will develop cellular screening systems on a unique arrestin-engineering platform to enable|high-throughput dissection of drug-induced GPCR signaling.