3-Dimensional Microtissues for Highly Predictive Drug Evaluation

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18391.1 PFLS-LS
• Titre du projet anglais: 3-Dimensional Microtissues for Highly Predictive Drug Evaluation

Description succincte (Allemand)

3-Dimensional Microtissues for Highly Predictive Drug Evaluation

Description succincte (Anglais)

3-Dimensional Microtissues for Highly Predictive Drug Evaluation

Résumé des résultats (Abstract) (Allemand)

Failure rates in drug development are unsustainably high and are most often attributed to poor performance of|a lead compound regarding safety and/or efficacy. Improving the predictive power of preclinical stage in vitro|tests for new drug safety and efficacy is key to reducing attrition. CellSpring¿s 3D Bloom microtissue platform|has shown promise for achieving these goals. This CTI project will enable the development and validation of|3D microtissue models for preclinical drug safety, preclinical efficacy testing for novel chemotherapeutics, and|automated handling for high throughput applications.

Résumé des résultats (Abstract) (Anglais)

Failure rates in drug development are unsustainably high and are most often attributed to poor performance of|a lead compound regarding safety and/or efficacy. Improving the predictive power of preclinical stage in vitro|tests for new drug safety and efficacy is key to reducing attrition. CellSpring¿s 3D Bloom microtissue platform|has shown promise for achieving these goals. This CTI project will enable the development and validation of|3D microtissue models for preclinical drug safety, preclinical efficacy testing for novel chemotherapeutics, and|automated handling for high throughput applications.