3-Dimensional Microtissues for Highly Predictive Drug Evaluation

• Research unit: INNOSUISSE
• Project number: 18391.1 PFLS-LS

Short description (German)

3-Dimensional Microtissues for Highly Predictive Drug Evaluation

Short description (English)

3-Dimensional Microtissues for Highly Predictive Drug Evaluation

Abstract (German)

Failure rates in drug development are unsustainably high and are most often attributed to poor performance of|a lead compound regarding safety and/or efficacy. Improving the predictive power of preclinical stage in vitro|tests for new drug safety and efficacy is key to reducing attrition. CellSpring¿s 3D Bloom microtissue platform|has shown promise for achieving these goals. This CTI project will enable the development and validation of|3D microtissue models for preclinical drug safety, preclinical efficacy testing for novel chemotherapeutics, and|automated handling for high throughput applications.

Abstract (English)

Failure rates in drug development are unsustainably high and are most often attributed to poor performance of|a lead compound regarding safety and/or efficacy. Improving the predictive power of preclinical stage in vitro|tests for new drug safety and efficacy is key to reducing attrition. CellSpring¿s 3D Bloom microtissue platform|has shown promise for achieving these goals. This CTI project will enable the development and validation of|3D microtissue models for preclinical drug safety, preclinical efficacy testing for novel chemotherapeutics, and|automated handling for high throughput applications.