A novel, localized approach to immune checkpoint modulation for the therapy of cancer

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18269.2 PFLS-LS
• Titre du projet anglais: A novel, localized approach to immune checkpoint modulation for the therapy of cancer

Description succincte (Allemand)

A novel, localized approach to immune checkpoint modulation for the therapy of cancer

Description succincte (Anglais)

A novel, localized approach to immune checkpoint modulation for the therapy of cancer

Résumé des résultats (Abstract) (Allemand)

The pathophysiology of chronic inflammation and epithelial cancer are casuatively linked. Interleukin (IL)-23 and IL-23 receptor (IL23R) expressing cells are heavily implicated in the development of various malignancies. In this project the potential of a bispecific antibody fragment specifically depleting IL23R expressing cells shall be evaluated to reactivate the host anti-cancer immune response.

Résumé des résultats (Abstract) (Anglais)

The pathophysiology of chronic inflammation and epithelial cancer are casuatively linked. Interleukin (IL)-23 and IL-23 receptor (IL23R) expressing cells are heavily implicated in the development of various malignancies. In this project the potential of a bispecific antibody fragment specifically depleting IL23R expressing cells shall be evaluated to reactivate the host anti-cancer immune response.