A novel, localized approach to immune checkpoint modulation for the therapy of cancer - Texts

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Research unit

INNOSUISSE

Project number

18269.2 PFLS-LS

Project title

A novel, localized approach to immune checkpoint modulation for the therapy of cancer

Texts for this project

	German	French	Italian	English
Short description		-	-
Abstract		-	-

Inserted texts

Category	Text
Short description (German)	A novel, localized approach to immune checkpoint modulation for the therapy of cancer
Short description (English)	A novel, localized approach to immune checkpoint modulation for the therapy of cancer
Abstract (German)	The pathophysiology of chronic inflammation and epithelial cancer are casuatively linked. Interleukin (IL)-23 and IL-23 receptor (IL23R) expressing cells are heavily implicated in the development of various malignancies. In this project the potential of a bispecific antibody fragment specifically depleting IL23R expressing cells shall be evaluated to reactivate the host anti-cancer immune response.
Abstract (English)	The pathophysiology of chronic inflammation and epithelial cancer are casuatively linked. Interleukin (IL)-23 and IL-23 receptor (IL23R) expressing cells are heavily implicated in the development of various malignancies. In this project the potential of a bispecific antibody fragment specifically depleting IL23R expressing cells shall be evaluated to reactivate the host anti-cancer immune response.