Total Synthesis of Picrinine and Alstolactines A-C

• Research unit: COST
• Project number: C16.0030

Key words (English)

Natural products; Alkaloids; Drugs; Total synthesis; Synthetic methodology; Structure-activity relationship

Research programs (English)

COST-Action CM1407 - Challenging organic syntheses inspired by nature: from natural products chemistry to drug discovery

Short description (English)

The objective of this project is to develop concise total synthesis of picrinine, alstolactines A, B and C. These complex polyheterocyclic monoterpene indole alkaloids are the main constituents of an investigatonal botanic drug that is now in phase II clinical trials in China. The plant extracts are being prescribed in hospital and are sold as traditional chinese medecine in drug stores. The realization of this project would not only provide access to these structurally complex alkaloids, but also analogues that will allow us to better define the structure-activity relationship of this class of natural products.

Partners and International Organizations (English)

AT; BE; BG; HR; CY; CZ; DK; EE; FI; FR; DE; EL; HU; IE; IL; IT; LV; LT; LU; NL; NO; PL; PT; RO; RS; SK; SI; ES; SE; TR; UK

Abstract (English)

See short description

References in databases (English)

Swiss Database: COST-DB of the State Secretariat for Education and Research Hallwylstrasse 4 CH-3003 Berne, Switzerland Tel. [phone] Swiss Project-Number: C16.0030