Regulation Of Animal Stem Cells By Signaling To Chromatin

• Forschungsstelle: COST
• Projektnummer: C15.0038
• Projekttitel Englisch: Regulation Of Animal Stem Cells By Signaling To Chromatin

Schlüsselwörter (Englisch)

Notch signaling; chromatin; Polycomb PRC2; DamID; stem cells; germline

Forschungsprogramme (Englisch)

COST-Action BM1408 - GENiE, A collaborative European network of C. elegans early-stage researchers and young principal investigators

Kurzbeschreibung (Englisch)

Specialized cellular microenvironments, or niches, control stem cells by diverse signaling pathways. However, how the signaling from a niche affects gene expression underlying stem cell behavior is poorly understood. We address this problem using the Caenorhabditis elegans model, in which maintenance of germline stem cells depends on Notch signaling from the gonadal niche. We have found that Notch activates numerous germline genes by antagonizing chromatin-based repression involving Polycomb Repressive Complex 2. Because a number of the activated genes are found to regulate self-renewal and differentiation, we hypothesize that a stem cell niche can control stem cell behavior by signaling to chromatin. This proposal is focused on elucidating the mechanism of Notch-dependent signaling to chromatin.

Weitere Hinweise und Angaben (Englisch)

Full name of research-institution/enterprise: Friedrich Miescher Institute for Biomedical Research Affiliated Institute of the University of Basel Senior group leader

Partner und Internationale Organisationen (Englisch)

AT; BE; CZ; DK; FI; FR; DE; EL; HU; IL; NL; NO; PL; PT; ES; SE; TR; UK

Abstract (Englisch)

See short description

Datenbankreferenzen (Englisch)

Swiss Database: COST-DB of the State Secretariat for Education and Research Hallwylstrasse 4 CH-3003 Berne, Switzerland Tel. [phone] Swiss Project-Number: C15.0038