Banking of human antibody repertoires for therapeutic use

• Unité de recherche: INNOSUISSE
• Numéro de projet: 18559.1 PFLS-LS
• Titre du projet anglais: Banking of human antibody repertoires for therapeutic use

Description succincte (Allemand)

Humane Antikörper Repertoire Bank als Basis für die Entwicklung von neuen Therapien

Description succincte (Anglais)

Banking of human antibody repertoires for therapeutic use

Résumé des résultats (Abstract) (Allemand)

MemoMAB is a technology enabling cost and time-effective molecular cloning and expression of the complete antibody repertoire from any type of B cell. The project goals are|(a) a robust MemoMAB process for human B-cells based on the established process for rabbit B cells,|(b) the use of this process for discovery of a preclinical mAb candidate for an infectious disease target, and (c) to establish a proprietary library of human antibody repertoires of clinically selected donors.

Résumé des résultats (Abstract) (Anglais)

MemoMAB is a technology enabling cost and time-effective molecular cloning and expression of the complete antibody repertoire from any type of B cell. The project goals are|(a) a robust MemoMAB process for human B-cells based on the established process for rabbit B cells,|(b) the use of this process for discovery of a preclinical mAb candidate for an infectious disease target, and (c) to establish a proprietary library of human antibody repertoires of clinically selected donors.