Humane Antikörper Repertoire Bank als Basis für die Entwicklung von neuen Therapien

• Forschungsstelle: INNOSUISSE
• Projektnummer: 18559.1 PFLS-LS
• Projekttitel Englisch: Banking of human antibody repertoires for therapeutic use

Kurzbeschreibung (Deutsch)

Humane Antikörper Repertoire Bank als Basis für die Entwicklung von neuen Therapien

Kurzbeschreibung (Englisch)

Banking of human antibody repertoires for therapeutic use

Abstract (Deutsch)

MemoMAB is a technology enabling cost and time-effective molecular cloning and expression of the complete antibody repertoire from any type of B cell. The project goals are|(a) a robust MemoMAB process for human B-cells based on the established process for rabbit B cells,|(b) the use of this process for discovery of a preclinical mAb candidate for an infectious disease target, and (c) to establish a proprietary library of human antibody repertoires of clinically selected donors.

Abstract (Englisch)

MemoMAB is a technology enabling cost and time-effective molecular cloning and expression of the complete antibody repertoire from any type of B cell. The project goals are|(a) a robust MemoMAB process for human B-cells based on the established process for rabbit B cells,|(b) the use of this process for discovery of a preclinical mAb candidate for an infectious disease target, and (c) to establish a proprietary library of human antibody repertoires of clinically selected donors.