Target validation in acute T cell-mediated inflammatory diseases.

• Unité de recherche: INNOSUISSE
• Numéro de projet: 17557.2 PFLS-LS
• Titre du projet anglais: Target validation in acute T cell-mediated inflammatory diseases.

Description succincte (Allemand)

Target validation in acute T cell-mediated inflammatory diseases..

Description succincte (Anglais)

Target validation in acute T cell-mediated inflammatory diseases.

Résumé des résultats (Abstract) (Allemand)

Our goal is to identify the key molecular target(s) responsible for the tissue damage observed in acute T cell-mediated inflammatory diseases (aTMID). Cytotoxic immune cells have been shown to play a pivotal role in the pathogenesis of aTMID. These cells exert their cytotoxic activities via effector proteins. Amongst them granulysin has been shown to play a central role. We aim at identifying potential synergies between granulysin and other putative effector proteins.

Résumé des résultats (Abstract) (Anglais)

Our goal is to identify the key molecular target(s) responsible for the tissue damage observed in acute T cell-mediated inflammatory diseases (aTMID). Cytotoxic immune cells have been shown to play a pivotal role in the pathogenesis of aTMID. These cells exert their cytotoxic activities via effector proteins. Amongst them granulysin has been shown to play a central role. We aim at identifying potential synergies between granulysin and other putative effector proteins.