Target validation in acute T cell-mediated inflammatory diseases.

• Research unit: INNOSUISSE
• Project number: 17557.2 PFLS-LS

Short description (German)

Target validation in acute T cell-mediated inflammatory diseases..

Short description (English)

Target validation in acute T cell-mediated inflammatory diseases.

Abstract (German)

Our goal is to identify the key molecular target(s) responsible for the tissue damage observed in acute T cell-mediated inflammatory diseases (aTMID). Cytotoxic immune cells have been shown to play a pivotal role in the pathogenesis of aTMID. These cells exert their cytotoxic activities via effector proteins. Amongst them granulysin has been shown to play a central role. We aim at identifying potential synergies between granulysin and other putative effector proteins.

Abstract (English)

Our goal is to identify the key molecular target(s) responsible for the tissue damage observed in acute T cell-mediated inflammatory diseases (aTMID). Cytotoxic immune cells have been shown to play a pivotal role in the pathogenesis of aTMID. These cells exert their cytotoxic activities via effector proteins. Amongst them granulysin has been shown to play a central role. We aim at identifying potential synergies between granulysin and other putative effector proteins.